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What are Exosomes?
Exosomes – the rising star in the aesthetic field!
Exosomes, tiny vesicles secreted by cells, have recently taken the spotlight in scientific and medical communities, generating an unprecedented level of excitement. Released during exocytosis, they function as extracellular vesicles that participate in the intercellular communication of various physiological and pathological processes.
Several Studies have shown that the content of exosomes mediates wound repair, has anti-aging effects), inhibits hyperpigmentation and signals pathway for collagen among many other regulatory mechanisms.
Exosomes can reduce the time from wound repair inflammation to remodeling.
Mesenchymal stem cell exosomes (MSCs-EXOs) encapsulated miR-223 regulate the polarization of macrophage M2 by targeting pknox1 and reducing the related inflammatory factor IL-10, TNF-α expression, thereby controlling the inflammatory response3
Putting the Science of Nature to Work
Applying a biomimetic approach to the science of beauty, the EXO|E™ Revitalizing Complex is a consortia of plant-based secretory factors, including plant-derived exosomes, that correspond to the skin’s needs. The bio-based patented technology helps support and supplement the skin’s balance.
The total solution of EXO|E™ carries the exosomes and other extracellular vesicles. The key ingredients in the solution are derived from the proprietary methodology of culturing Ustilago Cynodontis Ferment and the activation of stem cells from Piper Nigrum L and Withania Somnifera Root (Ashwagandha Root).
Consortia Factors ⍺1 – a comprehensive curated collection of potent, naturally occurring plant secretory factors to complement the course of aesthetic procedures
Within the process of cell activation, many cell-secreted factors are released into a conditioned medium (CM).1 EXO|E™ skin revitalizing complex is comprised of thousands of those plant secretory factors, that are all together referred to as CF - ⍺1. CF - ⍺1 includes: Growth factors, Peptides, Liposomes, Amino Acids, Proteins
What is PDRN?
PDRN is an innovation for skin rejuvenation. PDRN is extracted from the sperm of salmon trout, then carefully purified for aesthetic use. It's a mixture of deoxyribonucleotides with molecular weights ranging from 50 to 1,500 kDa.The purification process removes active proteins and peptides that may cause immune reactions
How it's used:
PDRN can be microneedled into the skin to treat hyperpigmentation, collagen synthesis and skin revitalization
How it works
PDRN activates adenosine A2A receptors, which promotes angiogenesis, cellular activity, and collagen synthesis
PDRN also provides nucleosides and nucleotides for the "salvage pathway"
PDRN lowers the expression of the pro-inflammatory cytokines IL-6 and TNF-alpha
PDRN is now available at Keystone Medical as an alternative to Exosomes for use with all microneedling services.